| 摘要 |
FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to benzo-[a] -quinolinone of the formula (I) <EMI ID=0.384 HE=36 WI=42 TI=CHI> where R is H, alkyl or phenalkyl; Z and Z' - are H, alkyl or one of Z and Z' with R forms a bond carbon-carbon Y is H or methyl or with SSS forms a band carbon-carbon; R is H or forms a bond carbon-carbon with one of Y or R ; R is H or C<SB>1-4</SB> alkyl; R is H or R forms a bond carbon-carbon; R is H or with R forms a bond carbon-carbon; R is H or with one of Z or Z' forms a bond carbon-carbon; n = 1 or 2; X is H, halogen, NO<SB>2</SB>, cyano-group, CF<SB>3</SB>, C<SB>1-6</SB>-alkyl, alkoxy-, carboxy-, alkoxycarbonyl-, amino-, amido-group or a group -A-O-R where A is C<SB>1-6</SB>-alkylene, C<SB>2-6</SB>-alkenyl or C<SB>2-6</SB>-alkynylene; R - halogen, hydroxy, alkylamido-group or its pharmaceutically acceptable salt. Compounds of the formula (I) are selective steroid inhibitors of 5alpha--reductase showing strong effect and can be used for treatment of patients with prostate benignity tumors, alopecia, acnes and seborrhea in males. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 19 cl, 1 tbl, 69 ex |
