| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes 1H-indole- -3-glyoxylamides of the formula (I) where X - both oxygen atoms; R<SB>1</SB> is (CH<SB>2</SB>)<SB>1-2</SB>-Ph-(R<SB>10</SB>)<SB>t</SB> or -CH<SB>2</SB>-Ph--(CH<SB>2</SB>)<SB>0-2</SB>-Ph; R<SB>10</SB> means independently halogen, C<SB>1</SB>-C<SB>10</SB>-alkyl, C<SB>1</SB>-C<SB>10</SB>-halogenalkyl; t = 0-5; R<SB>2</SB> is halogen, cyclopropyl, methyl, ethyl, propyl; R<SB>4</SB> and R<SB>5</SB> - each independently means: H, -(La)-(acid group) where La is an acid bridge group that for R<SB>4</SB> is taken from a group including of -OCH<SB>2</SB>-, -NH--CH<SB>2</SB>--, <EMI ID=0.691 HE=12 WI=42 TI=CHI>; R<SB>6</SB> and R<SB>7</SB> mean independently hydrogen, C<SB>1</SB>-C<SB>6</SB>-alkyl, or their pharmaceutically acceptable salts or their prodrug form as an aliphatic ester. Synthesized compounds are used for a pharmaceutical composition that inhibits nonpancreatic secretory phospholipase A<SB>2</SB> and taken at effective dose. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 9 cl, 2 tbl, 17 ex |
