发明名称 THIAZOLE DERIVATIVES
摘要 Compounds of the formula: as well as pharmaceutically usable salts and esters thereof, wherein R1, R2 and R3 have the significance ascribed herein, inhibit binding of adhesive proteins to the surface of different types of cell and accordingly influence cell-cell and cell-matrix interactions. These compounds can be used in the form of pharmaceutical preparations for the control or prevention of neoplasms, tumor metastasing, tumor growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, restenosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure, as well as infection caused by viruses, bacteria or fungi.
申请公布号 HRP980645(A2) 申请公布日期 1999.10.31
申请号 HR1998P000645 申请日期 1998.12.29
申请人 F. HOFFMANN - LA ROCHE AG 发明人 THOMAS WELLER
分类号 C07D277/20;A61K31/00;A61K31/425;A61K31/426;A61K31/427;A61K31/44;A61K31/4427;A61K31/4439;A61K38/00;A61P9/00;A61P13/00;A61P13/12;A61P17/00;A61P17/06;A61P19/00;A61P19/02;A61P19/08;A61P19/10;A61P27/00;A61P27/02;A61P31/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P35/04;A61P43/00;C07C275/26;C07C279/16;C07D277/38;C07D277/48;C07D277/56;C07D417/12;C07K5/117;(IPC1-7):C07D277/56;C07K5/10 主分类号 C07D277/20
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