| 发明名称 |
PROCESS TO MANUFACTURE SIMVASTATIN AND INTERMEDIATES |
| 摘要 |
A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
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| 申请公布号 |
CA2240983(A1) |
申请公布日期 |
1999.12.18 |
| 申请号 |
CA19982240983 |
申请日期 |
1998.06.18 |
| 申请人 |
APOTEX INC. |
发明人 |
TAM, TIM FAT;KARIMIAN, KHASHAYAR;LI, YIWEI;DOUCETTE, GARY;TAO, YONG |
| 分类号 |
C07D309/10;C07D309/30;(IPC1-7):C07D309/28 |
主分类号 |
C07D309/10 |
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