发明名称 |
Fremgangsmåte for kontinuerlig fremstilling av transdermale terapeutiske plastre |
摘要 |
A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance from their outer dimensions; the the resulting lattice-type refuse of the drug-free pressure-sensitive adhesive backing layer (1) is removed; and subsequently the protective layer (3) is cut in the resultant spaces between the drug reservoir sections (2). |
申请公布号 |
NO306849(B1) |
申请公布日期 |
2000.01.03 |
申请号 |
NO19930003414 |
申请日期 |
1993.09.24 |
申请人 |
LTS LOHMANN THERAPIE-SYSTEME GMBH & CO KG |
发明人 |
ANHOUSER, DIETER;DEURER, LOTHAR;HILLE, THOMAS;STEINBORN, PETER |
分类号 |
A61M37/00;A61K9/70;A61L15/44;A61M35/00;(IPC1-7):A61K9/70;A61F13/02 |
主分类号 |
A61M37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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