| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel compound which is useful for obtaining a benzoic acid derivative comprising a specific bicyclic amide compound, having retinoid activity and useful as medicines. SOLUTION: This benzoic acid derivative is a compound expressed by formula I (R1 is a lower alkyl or an aryl; R2 and R7 are each H or a lower alkyl; R3 to R6 are each a lower alkyl), e.g. 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6- acetaminonaphthalene. The compound of formula I is obtained by carrying out the Friedel-Crafts reaction using 1 mole of an acylated aniline derivative of formula II with preferably 1.5-2 mole of 1,4-dihalobutane derivative of formula III (X is a halogen) and preferably 1.5-2 mole of a Lewis acid (e.g. AlCl3, etc.), a protonic acid (e.g. sulfuric acid, etc.), etc., as a catalyst. As a solvent, a halogenated hydrocarbon is preferably used. It is preferable to carry out the reaction at temperatures ranging from a room temperature to a cooled temperature for 0.5-20 hours. |
