Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
申请公布号
CA2285516(A1)
申请公布日期
2000.11.12
申请号
CA19992285516
申请日期
1999.10.01
申请人
THE GENERAL HOSPITAL CORPORATION;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;ORGANIX, INC.
发明人
FISCHMAN, ALAN J.;MELTZER, PETER C.;BLUNDELL, PAUL;MADRAS, BERTHA K.;JONES, ALUN G.;MAHMOOD, ASHFAQ