发明名称 |
OPTICAL RESOLUTION OF AMINOISOBUTYRIC ACID |
摘要 |
A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recrystallizing the diastereomeric salts from ethyl acetate to separate the diastereomeric salts into crystal fractions; and (3) releasing the resolved acid from the diastereomeric salt by treating the diastereomeric salt with a basic solution is disclosed. A process for the preparation of the cryptophycin molecules is also disclosed.
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申请公布号 |
CA2310425(A1) |
申请公布日期 |
2000.12.09 |
申请号 |
CA20002310425 |
申请日期 |
2000.06.01 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
ZHANG, TONY YANTAO;AIKINS, JAMES ABRAHAM |
分类号 |
C07B57/00;C07C227/34;C07C229/08;(IPC1-7):C07C229/08;C07D413/06;C07C269/08;C07C227/20;C07C271/22 |
主分类号 |
C07B57/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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