发明名称 |
Modification of pertussis toxin |
摘要 |
The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
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申请公布号 |
US6168928(B1) |
申请公布日期 |
2001.01.02 |
申请号 |
US19980082514 |
申请日期 |
1998.05.21 |
申请人 |
CONNAUGHT LABORATORIES LIMITED |
发明人 |
READ RANDY J.;STEIN PENELOPE E.;COCKLE STEPHEN A.;OOMEN RAYMOND P.;LOOSMORE SHEENA;KLEIN MICHEL H.;ARMSTRONG GLEN D.;HAZES BART |
分类号 |
C07K14/235;G01N33/566;G01N33/68;(IPC1-7):C12N9/10;C12N9/14;C12N15/09;C12Q1/48;C12Q1/34 |
主分类号 |
C07K14/235 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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