Fremgangsmåte for fremstilling av (1R,4S)-2- azabicyklo[2.2.1]hept-5-en-3-on-derivater

摘要

A biotechnological method is described for preparing compounds of the general formulaswherein R<1 >is acyl or acyloxy and R<2 >is a hydrogen atom or C1-10 alkyl, comprising the conversion of a lactam of the general formulaby means of a hydrolase in the presence of a nucleophile and in the presence of a base in a constant pH range.Also described is the subsequent conversion of the compound of general formula I into the optically active 1-amino-4-(hydroxymethyl)-2-cyclopentene of the formula