摘要 |
<p>The present invention relates to an isolated C-terminal fragment of pro-interleukin 1β comprising a protein sequence having a molecular weight of 20-22 kD or an N-terminal truncation thereof, incorporating an interleukin-1β converting enzyme (ICE) cleavage site, the fragment being cleavable by ICE to produce active IL-1β, and the cleavage product thereof.</p> |