(-)-CIS-6(S)-PHENYL-5(R)-[4-(2-PYRROLIDINE-1-YLETHOXY)PHENYL]- -5,6,7,8-TETRAHYDRONAPHTHALENE-2-OL D-TARTRATE, METHOD OF ITS SYNTHESIS, METHOD OF PROPHYLAXIS OF STATES INFLUENCING WITH TO EFFECT OF ESTROGEN AGONISTS, PHARMACEUTICAL COMPOSITION

摘要

organic chemistry, pharmacy. SUBSTANCE: invention describes method of synthesis of (-)-cis-6(S)-phenyl-5(R)- -[4-(2-pyrrolidine-1-ylethoxy)phenyl] -5,6,7,8-tetrahydro- -naphthalene-2-ol D-tartrate that is useful as estrogen agonist and can be used for prophylaxis of states in mammals that can be influenced with effect of estrogen agonists, for example, in the case of osteoporosis, cardio-vascular disease, hyperlipidemia prostate disease, hypercholesterolemia, obesity, breast cancer, endometriosis. EFFECT: valuable medicinal properties of compound, improved method of synthesis. 11 cl, 1 ex