| 摘要 |
[Problem] To clarify the role of stem cell regulation factors, including Matrin-3, in cancer showing neural differentiation such as small cell cancer in the lung, and to develop a drug or the like which is useful for the treatment of cancer with relying on the role. [Solution] In some types of cancer which show a differentiation ability among various types of cancer which have a cancer stem cell regulation mechanism, both a stem cell-maintaining factor and a stem cell differentiation-accelerating factor are expressed at higher levels compared with normal cells and these factors keep a specific balance therebetween. In undifferentiated types of cancer among the above-mentioned various types of cancer, a stem cell-maintaining factor is expressed at a higher level compared with normal cells and these factors keep a specific balance therebetween. In some types of cancer in which the cancer stem cell regulation mechanism is present, there is a specific balance between these stem cell-regulating factors which is different from that in normal cells. In a cancer therapeutic drug and a cancer treatment method according to the present invention, the balance between the above-menioned stem cell-regulating factors is broken down to inhibit the proliferation ability of cancer. |
