| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of dibenzoxazepine or dibenzodioxepine of the formula (I) where R1 and R2 means independently hydrogen atom, unsubstituted lower alkyl or lower alkyl substituted with lower alkoxy-group or lower alkylthio-group or acyl-group that can be unsubstituted or substituted with one or some substituents taken among the group including lower alkyl, lower alkyl substituted with halogen atom or lower alkoxy-group; X means CO or CHOH; Y means CO or CH2; Z means O or NH, and their epimers and enantiomers or physiologically acceptable salts. Also, invention relates to antitumor pharmaceutical composition containing effective amount of compound of the formula (I). Compounds can be used as anticancer drugs. EFFECT: new compounds indicated above, valuable anticancer properties. 35 cl, 3 tbl |
