N-Phenyl-N'-Phenylpropylpiperazine derivatives and process for the preparation thereof.

摘要

N-Phenyl-N'-phenylpropylpiperazine derivatives represented by general formula (1) (wherein R<1> is lower alkyl; R<2> is lower alkoxy; and R<3> is cyano, carboxyl or indolecarbonyl); drugs containing the same; and a process for the preparation thereof. The compounds exhibit potent alpha 1-adrenergic receptor blocking activity and are useful in the prevention and treatment of hypertension, congestive heart failure, myocardial ischemia, arrhythmia, angina pectoris, urinary disturbance and frequent urination due to prostatic hypertrophy, and so on.