OXAZOLE DERIVATIVE HAVING ANTIBACTERIAL EFFECT

摘要

PURPOSE: A new oxazole derivative obtained by using amide as a starting material is provided which has a strong antibacterial effect on plant pathogenic bacteria with a small amount, for example Pyricularia oryzae Cavera, Rhizoctonia SolaniAG-1, Botrytis cinerea KCI, Phytophthora infestans or the like. CONSTITUTION: An amid compound(formula II) is refluxed in a solvent of dichloroacetone and ethanol to give chloromethyl oxazole(formula III). A chlorine atom of the chloromethyl oxazole is substituted to an iodine atom by use of sodium iodide and then reacted with 2-(2-hydroxyphenyl)-3-methoxy acrylic acid methylester(formula IV)(in case of A=C) or 2-methoxyimino-(2-hydroxyphenyl)-acetic acid methylester(formula IV)(in case of A=N) to produce an oxazole derivative(formula I).