MANUFACTURING METHOD OF ALKYLOXYAMINOFURANONE DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To provide a method by which an acid addition salt of an oxyaminofuranone derivative with high optical purity is obtained efficiently and in a high yield. SOLUTION: In the manufacture of an acid addition salt of a (4S, 5R)-5- alkyloxy-4-[(1R)-1-phenylethyl]amino-dihydro-furan-2-on] which is represented by formula (1) [wherein, R is an alkyl group], the acid addition salt of the compound represented by formula (1) is deposited from an aromatic hydrocarbon-based solvent containing the optical isomers of acid addition salt of 5-alkyloxy-4-[(1R)-1-phenylethyl]amino-dihydro-furan-2-on] which is represented by formula (2) [wherein R is as defined in formula (1)], and is then recovered.