NOVEL SALTS AND CO-CRYSTALS OF LESINURAD

摘要

Novel salts and cocrystals of lesinurad, processes for their preparation, pharmaceutical compositions comprising these new salt forms and co-crystals, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of uric acid transport 1 (URAT1) proteins are disclosed. These novel forms were characterized by X-ray powder diffraction, differential scanning calorimetry, and other techniques. They can be readily prepared and are suitable for preparation of solid dosage forms owing to their ease of handling and superior pharmacological properties.

主权项

1. A salt of the compound of formula (I): which is a crystalline calcium salt Form A, having an X-ray powder diffraction pattern comprising peaks with 2-theta values: 8.5°, 4.2°, and 17.1°, said 2-theta values may vary by ±0.2°.