USE OF INTERFERON-INDUCIBLE 2',5'-OLIGOADENYLATE-DEPENDENT RNase L IN THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF CANCER

摘要

A method of detecting cancer or a predisposition to cancer in a mammal, which method comprises detecting at least one mutation in a gene encoding interferon-inducible 2',5'-oligoadenylate-dependent RNase L (RNase L) in a test sample comprising a nucleic acid comprising the RNase L gene obtained from the mammal; a method of determining the level of nucleic acid comprising the wild-type RNase L gene and/or a mutant RNase L gene in a test sample comprising a nucleic acid comprising the wild-type RNase L gene and/or a mutant RNase L gene obtained from a mammal, which method comprises assaying the test sample for the level of nucleic acid comprising the wild-type RNase L gene and/or a mutant RNase L gene; a method for detecting cancer or a predisposition to cancer in a mammal, which method comprises detecting a mutant RNase L in a test sample comprising protein comprising RNase L obtained from the mammal; a method of determining the level of wild-type RNase L and/or a mutant RNase L in a test sample comprising protein comprising wild-type RNase L and/or a mutant RNase L obtained from a mammal , which method comprises assaying the test sample for the level of wild-type RNase L and/or a mutant RNase L; and a method of treating a mammal prophylactically or therapeutically for cancer, wherein the cancer is due to a complete or partial loss of wild-type RNase L, which method comprise providing RNase L to the mammal.