发明名称 |
Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations |
摘要 |
Non-lethal methods of conditioning a recipient prior to bone marrow transplantation to achieve highly enhanced, stable, long-term hematopoietic chimerism in presence of transient immunosuppression are described. In particular, the administration of non-lethal doses of bone-seeking radiopharmaceuticals such as 153Samarium Lexidronam, a radioactive compound linked to a tetraphosphonate group, to target bone marrow cells, are disclosed herein.
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申请公布号 |
US2003003051(A1) |
申请公布日期 |
2003.01.02 |
申请号 |
US20020166053 |
申请日期 |
2002.06.11 |
申请人 |
INVERARDI LUCA A.;RICORDI CAMILLO;PAGANELLI GIOVANNI;SERAFINI ALDO N. |
发明人 |
INVERARDI LUCA A.;RICORDI CAMILLO;PAGANELLI GIOVANNI;SERAFINI ALDO N. |
分类号 |
A61K51/00;A61K51/04;A61K51/10;A61P37/06;(IPC1-7):A61K49/00 |
主分类号 |
A61K51/00 |
代理机构 |
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地址 |
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