发明名称 CRYSTAL HAVING CRYSTAL HABIT, AND PHARMACEUTICAL COMPOSITION PREPARED BY TREATMENT OF SAID CRYSTAL
摘要 FIELD: chemistry.SUBSTANCE: invention relates to a luliconazole crystal presented by formula, wherein crystal has such a crystal habit, that (021) plane is its characteristic plane of crystal growth, in which Iin relation to total I, I, I, I, I, I, I, I, I, I, I, I, I, Iand Iis not less than 1/3, provided that relative to diffraction peaks, detected in range of 2θ=5-35° in x-ray powder diffraction using CuKα radiation, integral intensities of diffraction peaks, which correspond to (001), (100), (10-1), (011), (110), (11-1), (10-2), (11 -2), (020), (021), (20-2), (121), (013), (11-3) and (221) planes are designated as I, I, I, I, I, I, I, I, I, I, I, I, I, Iand Irespectively.EFFECT: invention aims at providing means to improve solubility of luliconazole.8 cl, 6 dwg, 4 tbl, 4 ex
申请公布号 RU2603963(C2) 申请公布日期 2016.12.10
申请号 RU20150109127 申请日期 2012.11.02
申请人 POLA FARMA INK. 发明人 MASUDA Takaaki
分类号 C07D409/06;A61K31/4178;A61P31/10 主分类号 C07D409/06
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