发明名称 |
NONPROTEIN STABILIZER FOR ATTENUATED CHICKENPOX LIVE VIRUS VACCINE |
摘要 |
PURPOSE: An attenuated chickenpox live virus vaccine containing a stabilizer which does not contain a protein component such as gelatin, etc. to minimize the possibility of inducing adverse effects in vaccination is provided which is high in manufacturing yield and long-term stability and permits maintenance of a high virus factor. CONSTITUTION: A stabilizer for attenuated chickenpox live virus vaccine contains a phosphoric acid buffer solution of pH 7.2 to 7.6 and 5 to 10%(v/v) of amino acid-mixed concentrated solution, based on the total volume of the stabilizer. The phosphoric acid buffer solution contains 7.5 to 15%(w/v) of sucrose, 0.05 to 0.1%(w/v) of potassium phosphate monobasic and 0.125 to 0.25%(w/v) of potassium phosphate dibasic. The attenuated chickenpox live virus vaccine is prepared by diluted with a nonprotein stabilizer to a concentration of chickenpox virus of 1.0x10¬4 to 2.0x10¬4PFU/ml.
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申请公布号 |
KR20030025480(A) |
申请公布日期 |
2003.03.29 |
申请号 |
KR20010058526 |
申请日期 |
2001.09.21 |
申请人 |
BORYUNG PHARMACEUTICAL CO., LTD. |
发明人 |
CHOI, JEONG SUN;JUNG, HAN SEON;LEE, SONG JAE;LIM, SANG MIN |
分类号 |
A61K47/36;(IPC1-7):A61K47/36 |
主分类号 |
A61K47/36 |
代理机构 |
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地址 |
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