ANALOGUES OF PEPTIDE LH-RF, THEIR APPLICATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF

摘要

FIELD: medicine, biomolecular endocrinology, hormones, peptides. SUBSTANCE: invention relates to the creation of analogues of peptide releasing factor of luteinizing hormone (LH-RF) exhibiting affinity to LH-RF receptors and having the following formula: A1-A2- A3-A4-A5- A6-HAA-A7-Pro-Z wherein values Z and from A1 to A7 are amino acids and their derivatives; HAA is nonaromatic hydrophobic amino acid comprising from 7 to 20 carbon atoms. Invention relates also to their application and pharmaceutical compositions. EFFECT: valuable medicinal properties of compositions, expanded assortment of gonadotropic agents. 19 cl, 4 tbl, 30 ex