发明名称 |
Methods and compositions for vaccination against or involving enterobacteriaceae bacteria |
摘要 |
The present invention concerns the use of methods and compositions to prophylactically or therapeutically vaccinate a subject against a pathogen or disease. Embodiments of the invention include the production of an attenuated bacterium from the family Enterobacteriaceae with a non-functional lipoprotein for use as a vaccine or as a vaccine vector for delivering antigens to a subject to be vaccinated. In certain embodiments, a bacterium of the Enterobacteriaceae family lacking a wild type LP, for example Salmonella typhimurium lacking a wild type LP, may be produced and used as a vaccine or vaccine vector.
|
申请公布号 |
US2003215464(A1) |
申请公布日期 |
2003.11.20 |
申请号 |
US20030394517 |
申请日期 |
2003.03.20 |
申请人 |
KLIMPEL GARY R.;NIESEL DAVID W.;CHOPRA ASHOK;SHA JIAN |
发明人 |
KLIMPEL GARY R.;NIESEL DAVID W.;CHOPRA ASHOK;SHA JIAN |
分类号 |
A61K39/02;A61K39/108;A61K39/112;C12N1/21;C12N1/36;(IPC1-7):A61K39/02 |
主分类号 |
A61K39/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|