| 发明名称 |
Pyrazinones, compositions containing such compounds and methods of use |
| 摘要 |
Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters, N-oxides and hydrates thereof are disclosed. Pharmaceutical compositions and methods of use are also included. The compounds are active against the caspase-3 enzyme, and thus are useful to treat caspase-3 mediated diseases and conditions.
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| 申请公布号 |
US2003236402(A1) |
申请公布日期 |
2003.12.25 |
| 申请号 |
US20020202817 |
申请日期 |
2002.07.25 |
| 申请人 |
MERCK FROSST CANADA & CO. |
发明人 |
HAN YONGXIN;GIROUX ANDRE;ZAMBONI ROBERT;MCKAY DANIEL J.;BAYLY CHRISTOPHER I.;GRIMM ERICH L.;COLUCCI JOHN |
| 分类号 |
C12N9/99;A61K31/4965;A61K31/497;A61K31/4985;A61K38/00;A61P3/10;A61P17/14;A61P21/00;A61P25/00;A61P25/16;A61P25/28;A61P31/04;A61P31/18;A61P37/02;A61P43/00;C07D241/20;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D413/14;C07D417/12;C07D471/04;C07D487/08;C07D491/08;C07K5/083;(IPC1-7):C07D417/02;C07D413/02;C0743/02;A61K31/541;A61K31/537;A61K31/496 |
主分类号 |
C12N9/99 |
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