Radiolabeled alpha-melanocyte stimulating hormone hybrid peptide for melanoma targeting

摘要

The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue, suggesting favorable selective activity of compounds according to the present invention, which can be used as effective therapeutic agents against melanoma, including metastatic melanoma. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are useful to initiate therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic and therapeutic tools for a number of conditions and diseases states, especially melanoma.

主权项

1. A compound according to the chemical structure: Where Q is glutamic acid; R is valine; V is aspartic acid; W is aspartic acid; X is an amino acid residue selected from the group consisting of alanine, valine, threonine and serine; Y is aspartic acid or glutamic acid; L is alanine or a linker group according to the chemical structure: where p is an integer from 0 to 8; and M is a radioisotope, or a pharmaceutically acceptable salt thereof.