| 摘要 |
FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to the improved method for preparing water- soluble salts of amino acid derivatives of fullerene that can be used in medicine, pharmacology and microbiology. Invention describes method for preparing water-soluble salts of amino acid derivatives of fullerene of the general formula HC60NH(CH2)nCOOM wherein C60 is a fullerene ring; M is alkaline metal; n = 1, 3, 5. Method involves interaction of fullerene with amino acid salt in an organic solvent medium at heating and the following isolation of the end product. Interaction reaction is carried out in the presence of low-molecular polyalkylene oxide with molecular mass 150-400 Da. Invention provides reduced time for process carrying out, reduced cost of end product based on using available and inexpensive raw. EFFECT: improved preparing method. |
