发明名称 |
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
摘要 |
A cytotoxic agent comprising one or more modified doxorubicins/daunorubicin linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more modified doxorubicins/daunorubicins covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more modified doxorubicins/daunorubicins linked to a cell binding agent. Novel sulfur-containing modified doxorubicins/daunorubicins.
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申请公布号 |
NZ518764(A) |
申请公布日期 |
2004.02.27 |
申请号 |
NZ20000518764 |
申请日期 |
2000.12.19 |
申请人 |
IMMUNOGEN, INC |
发明人 |
CHARI, RAVI V J;BLATTLER, WALTER A |
分类号 |
C07H19/04;A61K31/706;A61P31/04;A61P31/12;A61P33/00;A61P35/00;A61P37/02;A61P43/00;C07H15/252;C07H19/24;(IPC1-7):C07H15/252;A61K31/704 |
主分类号 |
C07H19/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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