A process for purification of dimeric to pentameric proanthocyanidin oligomers with uniform polymerization degree

摘要

A process for purification of dimeric to pentameric proanthocyanidin oligomers with a uniform polymerization degree which comprises: separating and purifying the proantocyanidin oligomers by polymerization degree from raw materials containing dimeric to pentameric proanthocyanidin oligomers or crude purification products therefrom by normal phase silica gel liquid chromatography according to isocratic elution using as a mobile phase a single solvent or mixed solvent of two or more solvents selected from the group consisting of an ester solvent, a ketone solvent, a hydrocarbon solvent, an ether solvent and an alcohol solvent.