| 摘要 |
<P>PROBLEM TO BE SOLVED: To develop a homologous recombination method for simply and rapidly producing a knockout non-human animal in which a blood level of an adiposity promoting protein and/or an expression level itself are changed or the adiposity promoting protein is eliminated by destroying a part or all of the genomic gene of the adiposity promoting protein, and to provide the knockout non-human animal produced by using the homologous recombination method. <P>SOLUTION: In this non-human animal or a part thereof comprising an individual of the knockout non-human animal, a descendant animal or the part thereof, all or one of allyls in a diploid of the genomic gene of the adiposity promoting protein having a ≥ about 6,000 molecular weight are substituted with dysfunctional mutant genes, or all or one of the allyls in the diploid of the genomic gene are destroyed so that their functions are deleted. A method for evaluating glucolipid metabolism control ability is provided by using the non-human animal or the part thereof. <P>COPYRIGHT: (C)2004,JPO |
