| 摘要 |
<p>Disclosed are DNA elements and constructs useful for obtaining tumour selective gene expression in tumours having a mutated bgr; catenin APC pathway. In particular, the use of these constructs to express genes encoding therapeutic proteins in colorectal cancer cells is described. The constructs comprise multiple repeats of a TCF binding element operably linked to a promoter. By means of such a construct, tumour cell specific expression of a prodrug converting enzyme such as nitroreductase may be achieved. Coupled with systemic administration of a suitable prodrug, such as CB1954, selective killing of such tumour cells can be demonstrated.</p> |
