Microfluidic Particle Analysis Method, Device And System

摘要

The method, device, and system relate to particle analysis, and in particular, to a microfluidic device designed for trapping particles for analysis. Particles include beads and cells.

主权项

1. A microfluidic particle analysis device comprising:
a microluidics body; a microfluidics channel in said body holding a fluid flow of a liquid containing one or more cell-sized particles, said fluid flow provided via a port in communication with said microfluidics channel; and at least one trapping region in said microfluidics channel, said at least one trapping region comprising a deformable wall portion configured to have two operational heights when subjected to two different operational pressures, the two operational heights of the deformable wall portion, comprising: a first height configured to allow one or more cell-sized particles of interest to pass into said trapping region via said fluid flow in said channel; and a second height configured to trap one or more cell-sized particles of a given size within said trapping region of said channel by physically contacting said one or more cell-sized particles, such that said one or more cell-sized particles having the given size are selectively retained in said trapping region by a change in physical dimensions of said trapping region caused by a change in operational pressure.