发明名称 |
Bakterielle antigener, vacciner og fremgangsmåder til fremstilling af antigenet |
摘要 |
Antigens and vaccines containing purified oligomers (1-50 units) of the repeating pentasaccharide unit of type III Group B Stretococcus (III GBS) polysaccharide capsule. Methods of making the antigen by recovering polysaccharide from cultured III GBS or medium and digesting the polysaccharide with a specific endo- beta -galactosidase. Enzymatic cleavage of bacterial polysaccharide to make purified oligomers. A purified trypsin-resistant C surface protein, m.w. about 14,000 and vaccine. Passive immunization using the above vaccines. Immunoassays for GBS immunodeterminants or anti-GBS antibodies. |
申请公布号 |
DK175487(B1) |
申请公布日期 |
2004.11.08 |
申请号 |
DK19870006566 |
申请日期 |
1987.12.15 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
KASPER, DENNIS L.;JENNINGS, HAROLD J.;LEVY, NANCY J.;WESSELS, MICHAEL R. |
分类号 |
A61K39/09;A61K39/395;A61K39/40;C07H3/06;C07H13/06;C07K14/00;C07K14/005;C07K14/195;C07K14/315;C07K14/34;C07K14/41;C07K14/705;C07K16/00;C07K16/12;C07K17/02;C08B37/00;C12N9/38;C12P19/04;C12P19/26;C12P21/00;C12P21/08;C12R1/46;G01N33/569 |
主分类号 |
A61K39/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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