发明名称 |
Site specific binding system, imaging compositions and methods |
摘要 |
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
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申请公布号 |
US6821506(B2) |
申请公布日期 |
2004.11.23 |
申请号 |
US20010036317 |
申请日期 |
2001.12.28 |
申请人 |
BARNES-JEWISH HOSPITAL |
发明人 |
LANZA GREGORY M.;WICKLINE SAMUEL A. |
分类号 |
A61K49/00;A61K49/18;A61K51/12;G01N33/58;(IPC1-7):A61B5/055 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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