发明名称 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
摘要 A compound of formula (I) wherein T is a monocyclic aryl ring or monocyclic heteroaryl ring, optionally independently substituted by [R]n, wherein n is an integer 0-5, and R is hydrogen, C1-6-alkyl, halogen, aryl or aryloxy, wherein the aryloxy residue can further be optionally substituted in one or more positions independently of each other by cyano and halogen; with the proviso: that when A is methyl and B is hydrogen, then T is not phenyl; that when A is methyl and B is 2,2,2-trichloroethyl, then T is not 4-methylphenyl; that when A is methyl and B is hydrogen, then T is not 4-bromophenyl; that when A is isobutyl and B is hydrogen, then T is not phenyl; that when A is isobutyl and B is hydrogen, then T is not 4-methylphenyl; that when A is methyl and B is hydrogen, then T is not 4-methylphenyl; A is C1-6-alkyl, vinyl or 3-(ethyl 3-methylbutanoate); B is hydrogen, methyl, ethyl, n-propyl, n-butyl, halogenated C1-6-alkyl, C1-6-acyl or C1-6-alkoxycarbonyl; as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
申请公布号 NZ522507(A) 申请公布日期 2004.11.26
申请号 NZ20010522507 申请日期 2001.05.22
申请人 BIOVITRUM AB 发明人 BARF, TJEERD;NILSSON, MARIANNE;KURZ, GUIDO;VALLGARDA, JERK
分类号 C07D277/20;A61K31/426;A61K31/427;A61K31/428;A61K31/429;A61K31/437;A61K31/4439;A61K31/4709;A61K31/4725;A61K31/496;A61K31/506;A61K31/5377;A61K31/541;A61K31/553;A61P3/00;A61P3/04;A61P3/06;A61P3/08;A61P3/10;A61P5/48;A61P9/04;A61P19/10;A61P25/24;A61P25/28;A61P27/06;A61P29/00;A61P31/06;A61P31/12;A61P43/00;C07D277/28;C07D277/38;C07D277/48;C07D277/52;C07D277/56;C07D277/58;C07D277/60;C07D277/82;C07D277/84;C07D417/04;C07D417/06;C07D417/12;C07D417/14;C07D491/08;C07D513/04;C07D521/00;(IPC1-7):C07D277/52 主分类号 C07D277/20
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