发明名称 |
PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE |
摘要 |
The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts. |
申请公布号 |
HRP20161291(T1) |
申请公布日期 |
2016.11.18 |
申请号 |
HR2016P001291T |
申请日期 |
2016.10.06 |
申请人 |
WisTa Laboratories Ltd. |
发明人 |
Marshall, Colin;Clunas, Scott;Storey, John Mervyn David;Sinclair, James Peter;Baddeley, Thomas Craven;Ishaq, Ahtsham;Simpson, Michael;Williamson, Craig;Wood, Barry Alan;Wischik, Claude Michel;Harrington, Charles Robert;Rickard, Janet;Horsley, David;Loh, Yin Sze;Khan, Karrar Ahmad;Larch, Christoper Paul |
分类号 |
C07D279/20;A61K31/5415;A61P25/00 |
主分类号 |
C07D279/20 |
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