发明名称 MODIFIED FACTOR VIII.
摘要 <p>The invention relates to the modification of human Factor VIII (FVIII) to result in FVIII proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The invention relates furthermore to T-cell epitope peptides derived from said non-modified protein by means of which it is possible to create modified FVIII variants with reduced immunogenicity.</p>
申请公布号 MXPA04010061(A) 申请公布日期 2004.12.13
申请号 MX2004PA10061 申请日期 2003.04.17
申请人 MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG 发明人 MATTHEW BAKER
分类号 C12N15/09;A61K38/00;A61K38/10;A61K38/36;A61K38/37;A61K39/00;A61P7/00;A61P7/04;A61P37/06;C07K7/08;C07K14/755;C12N15/12;C12P21/02;(IPC1-7):A61K38/10 主分类号 C12N15/09
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