Methods for identifying inhibitors of cytochrome P450RAI

摘要

A method of identifying a compound which is an inhibitor of the enzyme cytochrome P450RAI is performed by selecting a compound that has retinoid activity in an art recognized assay and includes a benzoic acid, benzoic acid ester, naphthoic acid ester or heteroaryl carboxylic acid or ester moiety, with a partial structure of -A(R2)-(CH2)n-COOR8 where n is 0 and the remaining variables are as described in the specification and claims. Thereafter, a compound having the cytochrome P450RAI inhibitory activity is identified and selected where the compound has the -A(R2)-(CH2)2-COOR8 partial structure wherein the variable n is 1 or 2.