发明名称 |
HUMANIZED C5 AND C3 ANIMALS |
摘要 |
Non-human animals comprising a human or humanized C3 and/or C5 nucleic acid sequence are provided as well as methods for using the same to identify compounds capable of modulating the complement system. Non-human animals that comprise a replacement of the endogenous C5 gene and/or C3 gene with a human or humanized C5 gene and/or C3 gene, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized C5 gene under control of non-human C5 regulatory elements is also provided, including non-human animals that have a replacement of non-human C5-encoding sequence with human C5-encoding sequence at an endogenous non-human C5 locus. Non-human animals comprising a human or humanized C3 gene under control of non-human C3 regulatory elements is also provided, including non-human animals that have a replacement of non-human C3 protein-encoding sequence with human or humanized C3 protein-encoding sequence at an endogenous non-human C3 locus. Non-human animals comprising human or humanized C3 and/or C5 sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided. |
申请公布号 |
SG11201608696R(A) |
申请公布日期 |
2016.11.29 |
申请号 |
SG11201608696R |
申请日期 |
2015.05.04 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
HU, YING;LATUSZEK, ADRIANNA;CAO, JINGTAI;MUJICA, ALEXANDER;WIEGAND, STANLEY;MCWHIRTER, JOHN;MURPHY, ANDREW;MACDONALD, LYNN |
分类号 |
A01K67/027;A61K49/00;C07K14/47;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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