| 摘要 |
<P>PROBLEM TO BE SOLVED: To obtain an antimicrobial peptide-containing substance that is stable in pH in the neutral range to the alkaline range, especially from the acid to alkalinity ranges, and a new lactic acid bacterium for producing the substance. <P>SOLUTION: The lactic acid bacterium (typically KMR-7 strain) belongs to Lactococcus lactis subsp. lactis capable of producing a peptide-containing substance that is stable at pH 2-9 and exhibits antimicrobial properties against gram-positive bacteria. The antimicrobial substance is obtained by culturing the lactic acid strain and has the following properties of (a) containing antimicrobial peptide or protein, (b) completely being digested by protease, (c) being stable at pH 2-9, especially exhibiting high stability at pH 5-9 and (d) exhibiting heat stability at pH 7.0 at 110°C for 10 minutes. The method for producing the antimicrobial substance comprises culturing the lactic acid strain and collecting the cultured cell. The lactic acid strain is used for producing a food. The food preservative contains the antimicrobial substance or a substance containing it. The fermentation raw material or fermented food is produced by using the lactic acid strain. <P>COPYRIGHT: (C)2005,JPO&NCIPI |
