Substituted benzopyran derivatives against arrhythmia

摘要

Disclosed are benzopyran derivatives of formula (1) and formula (2), wherein: R1 and R2 are independently H or optionally substituted alkyl, R3 is hydroxyl or alkylcarbonyloxy, R4 is H or alkyl, R5 is C2-6alkyl substituted with aryl or heteroaryl wherein the C2-6alkyl may be further substituted, or a straight-chain C5-8alkyl optionally substituted with fluorine or hydroxyl, R6 is optionally substituted alkylalkoxy, halogen, C(O)NH2, C(O)NHR8 or C(O)NR8R9, and the remaining substituents are defined herein. The benzopyran derivatives are used in the manufacture of medicaments for the treatment of arrhythmia.