Naturally-occurring variants of human Rgr oncogene protein, in particular, abnormally truncated variants found in T cell malignancies, as well as the human Rgr protein are encompassed by the present invention. Also included are antibodies thereto and nucleic acid molecules encoding human Rgr protein and naturally-occurring variants thereof. The present invention further provides methods for diagnosing and treating T cell malignancies associated with abnormally truncated transcripts of human rgr oncogene and/or abnormal truncation of human Rgr protein.
申请公布号
WO2004009783(A3)
申请公布日期
2005.05.06
申请号
WO2003US22819
申请日期
2003.07.23
申请人
NEW YORK UNIVERSITY;PELLICER, ANGEL;LEONARDI, PETER;INGHIRAMI, GIORGIO
发明人
PELLICER, ANGEL;LEONARDI, PETER;INGHIRAMI, GIORGIO