发明名称 |
APTAMER CONSTRUCTS |
摘要 |
Provided are RNA oligonucleotides having an aptamer flanked by two self-cleaving ribozymes. Vectors encoding the oligonucleotides, and cells transfected with these vectors are also provided. Additionally, methods of inhibiting replication of a virus in a cell, methods of treating an organism with an aptamer, methods of determining whether a test aptamer is effective in inhibiting the function of a target of the aptamer in a cell, and methods of expressing an RNA aptamer in a cell are provided. |
申请公布号 |
WO03102146(A3) |
申请公布日期 |
2005.05.06 |
申请号 |
WO2003US17182 |
申请日期 |
2003.05.29 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY;PRASAD, VINAYAKA, R.;JOSHI, PHEROZE |
发明人 |
PRASAD, VINAYAKA, R.;JOSHI, PHEROZE |
分类号 |
C07H21/02;C07K14/16;C12N15/113;C12N15/115;C12N15/867;C12Q1/70 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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