CHEMICAL SYNTHESIS AND ANTICANCER AND ANTIMETASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE

摘要

FIELD: chemistry.SUBSTANCE: invention relates to dual functional conjugate of formula i, where docetaxel is linked with muramyl dipeptide derivative, which enables to achieve anticancer and antimetastatic effect. Method of producing conjugate is carried out by combination of solid-phase and liquid-phase synthesis.EFFECT: invention also discloses a pharmaceutical composition and use of conjugate for producing anti-tumour drugs.21 cl, 29 dwg, 13 tbl, 51 ex