| 发明名称 |
MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS |
| 摘要 |
The present invention relates to the preparation of β-lactam antibodies comprising contacting 4-hydroxyphenylglycine of phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation. |
| 申请公布号 |
US2016362715(A1) |
申请公布日期 |
2016.12.15 |
| 申请号 |
US201615252636 |
申请日期 |
2016.08.31 |
| 申请人 |
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. |
发明人 |
MUELLER Ulrike Maria;BOER Rémon;BOVENBERG Roelof Ary Lans |
| 分类号 |
C12P37/00;C12N15/70;C12N9/02 |
主分类号 |
C12P37/00 |
| 代理机构 |
|
代理人 |
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| 主权项 |
|
| 地址 |
Delft NL |
