摘要 |
The present invention relates to an in vitro method for the prognosis or prediction of the response to treatment with anti-psychotic drugs in subjects who have suffered first episode psychosis (FEP), and specifically to the use of the expression value, in a biological sample isolated from said subjects, of the ratio formed by two of the isoforms – active isoform and truncated isoform – of the receptor (TrKB) of the nerve growth factor BDNF, named TrKB-FL and TrkB-T, respectively. The present invention also describes kits and uses of same to implement the method of the invention. |
申请人 |
CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED;UNIVERSIDAD DEL PAÍS VASCO/EUSKAL HERRIKO UNIBERTSITATEA;ADMINISTRACIÓN GENERAL DE LA COMUNIDAD AUTÓNOMA DE EUSKADI;HOSPITAL CLINIC;UNIVERSIDAD COMPLUTENSE DE MADRID;UNIVERSITAT DE BARCELONA;UNIVERSIDAD DE CÁDIZ;UNIVERSIDAD DE OVIEDO;UNIVERSIDAD DE ZARAGOZA |
发明人 |
MARTÍNEZ CENGOTITABENGOA, Mónica;GONZÁLEZ-PINTO, Ana María;ALBERICH MESA, Susana;LEZA CERRO, Juan Carlos;MACDOWELL MATA, Karina;PARELLADA REDONDO, María José;RODRÍGUEZ JIMÉNEZ, Roberto;BERNARDO ARROYO, Miguel;SÁIZ MARTÍNEZ, Pilar Alejandra;MICÓ SEGURA, Juan Antonio;LOBO SATUÉ, Antonio;MATUTE ALMAU, Carlos |