NEW CRYSTAL FORM OF APREMILAST AND PREPARATION METHOD THEREFOR

摘要

The present invention provides an Apremilast new crystal form B+ as shown in formula (I), which has the characteristic absorption peaks as follows within 2θ±0.2 in an X-ray powder diffraction pattern: 11.03, 12.97, 13.31, 13.65, 14.52, 16.01, 17.74, 18.54, 22.55, and 26.75. Compared with the prior art, the Apremilast crystal form B+ provided by the present invention has a large granularity, good fluidity, as well as desirable stability, hygroscopicity, and solubility. The present invention further provides a preparation method for the new crystal form B+, comprising: dissolving Apremilast in a solvent, decreasing a system temperature after the Apremilast is completely dissolved, crystallizing, filtering, and drying the solid in a drying oven till the weight is constant, thus obtaining the new crystal form of the Apremilast.