发明名称 |
METHODS FOR MONITORING CD4+ T-HELPER TYPE 1 RESPONSE IN CANCER AND IMMUNE RESTORATION |
摘要 |
A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer CD4+ Th1 response from antigen presenting cells or their precursors and CD4+ T-cells from a sample of said subject's blood which causes secretion of interferon-gamma ("IFN-γ"); and detecting said anti-cancer CD4+ Th1 response to determine if said response is depressed. A method for restoring HER2-specific CD4+ Th1 immune response in a HER2-positive breast cancer patient in need thereof, comprising: administering to said patient a therapeutically effective amount of a dendritic cell ("DC") vaccine comprising autologous DCs pulsed with HER2-derived MHC class II binding peptides ("DC vaccination") to elevate said patient's anti-HER2 CD4+ Th1 response; and measuring said anti-HER2 Th1 response of said patient pre- and post-DC vaccination to determine the amount of increase in said response. |
申请公布号 |
WO2016153761(A1) |
申请公布日期 |
2016.09.29 |
申请号 |
WO2016US20987 |
申请日期 |
2016.03.04 |
申请人 |
CZERNIECKI, Brian, J. |
发明人 |
CZERNIECKI, Brian, J.;KOSKI, Gary, K.;DATTA, Jashodeep |
分类号 |
C12N5/078;A61K35/12;A61K35/17;A61K38/19;A61K38/20;C12N5/0784 |
主分类号 |
C12N5/078 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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