| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a compound of structural formula I , its pharmaceutically acceptable salt or stereoisomer, where X is -CH- or -N-; n equals 0, 1, 2 or 3; m equals 0, 1 or 2; R1 and R4 are each independently selected from hydrogen, halogen, cyano, perfluoroC1-6alkyl, C1-10alkyl, C2-10alkenyl, C3-8cycloalkylC0-10alkyl, R5 is hydrogen; R2 and R3 are each independently selected from hydrogen, hydroxyC0-10alkyl, perfluoroC3-6alkyl, C1-10alkyl, C3-8cycloalkylC0-10alkyl, (C0-10alkyl)1-2aminocarbonyloxyC0-10alkyl, C3-8heterocyclylcarbonyloxyC0-10alkyl, to their use in making a medicinal agent with activity which his mediated with androgen receptor modulation (SARM), as well as to a pharmaceutical composition and preparation method thereof. ^ EFFECT: novel compounds which can be used as androgen receptor modulators (SARM) are obtained and described. ^ 15 cl, 5 ex, 4 tbl |
