| 摘要 |
Furan propylamine drug intermediates 2-furan acrylic acid synthesis method comprises the following steps: equipped with a stiffer and a reflux condenser, a reaction vessel was added 3. 1mol 2-chloro-furan-methanol solution, 3.6--3.9 mol malonic acid solution (3), 300ml nitroethane solution, control stirred speed for 130--170rpm, the solution temperature is raised to 70 - 75 C, refluxed for 5--8 h, the temperature of the solution is reduced to 8 -- 13 C, added 310ml sodium bromide solution, 200ml solution of potassium hydrogen sulfite, control the reaction time to 90-120 min, standing for 3- 6 h, the precipitated solid was filtered, washed with salt solution, washed with toluene solution, washed with ethylenediamine solution, dehydrated with dehydrating agent, recrystallized in propionitrile solution, ultimately got 2-furyl acrylic acid crystals. |
